Table 2.
Clinical trials without clear evidence of J-curve effect
| Author | Subjects | Age (yr) | Follow-up (yr) | Baseline (DBP mmHg) | CAD (present) | J-curve effect MI | Stroke | DBP (mmHg) |
| Wilhelmsen et al[26] | 6569 | 40-60 | 3.9 | 107 | Yes | Yes2 | No | 88-89 |
| Coope et al[27] | 884 | 60-79 | 4.4 | 98 | Yes | Yes1 | No | 80-89 |
| Lubsen et al[29] | 7661 | 63.0 | 4.9 | 85 | Yes | Yes3 | No | 85 |
| Psaty et al[30] | 4702 | 72.6 | 6.7 | 71 | No | No | No | 62 |
| Glynn/PHS[31] | 22 071 | 53.2 | 13.0 | 79 | Yes | No | No | 65 |
| Glynn/WHS[31] | 39 876 | 53.8 | 6.2 | 78 | No | No | No | 70 |
1
Present in female smokers;
2
Present for trend;
3
Present for trend. CAD: Coronary artery disease; DBP: Diastolic blood pressure; MI: Myocardial infarction.