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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Nat Immunol. 2011 Feb 27;12(4):295–303. doi: 10.1038/ni.2005

Figure 4.

Figure 4

T-Rheb−/− mice do not develop EAE, but instead develop an alternative autoimmune disease. (a) Disease progression of wild-type and T-Rheb−/− mice immunized with MOG and CFA to induce EAE (n=7, **, p < 0.01 by one-way ANOVA). (b) Immunohistochemistry (IHC) for CD45 and CD4 of CNS sections frozen at the height of disease in wild-type mice. (c) Cytokine production of CNS samples rested in unsupplemented media for 16 h and stimulated with PMA and ionomycin in the presence of a protein transport inhibitor (n = 4, p values indicated are from Student’s t test). Plots are gated by CD4 expression and side scatter. (d) Incidence of classical or nonclassical EAE in our system. (e) As in b, but sections of cerebellum are shown. Data are representative of 3 independent experiments.