Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Hypo-osmolar stress rapidly and transiently disrupts BBB monolayers. Confluent bEnd3 monolayers were exposed to continuous ISO or continuous HYPO, with or without 1 μM RR for 2 hours and paracellular permeability was measured. HYPO caused a rapid increase in [14C]sucrose permeability that was partially inhibited by co-treatment with RR. This increase from 5–15 min was gone after 30 min. Graphs represent data from 4 separate permeability experiments, n = 6–16, * p<0.05 versus time 0.
