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. Author manuscript; available in PMC: 2011 Apr 15.
Published in final edited form as: Immunogenetics. 2010 Sep 30;62(11-12):773–780. doi: 10.1007/s00251-010-0481-9

Figure 2. Polymorphic variation of known MCM MHC class I transcripts.

Figure 2

Distribution of nucleotide variability for MCM MHC class I products. We aligned all 67 distinct MCM MHC class I sequences identified by pyrosequencing and plotted the frequency of the nucleotide differences. Below the variability plot is a depiction of the cDNA-PCR amplicons used in this study as well as the location of the 190-base pair amplicon used previously (Wiseman et al. 2009). Above the variability plot is a depiction of the macaque MHC class I domain structure. The alpha 1 and alpha 2 domains form the highly polymorphic peptide-binding pocket of the MHC class I transcript.