Table 2.

Relationship of clinical variables to functional classification of p53 germline alleles based on DN90. For each allele, the DN effect was determined quantitatively (luciferase-based) in 4 different reporter strains. Alleles were classified as DN or recessive (rec) if they reduced (or not) the transactivation activity of the WT allele to less than 90% (DN90), respectively, in at least one of the four reporter strains. The p values are for testing whether the proportion of families exhibiting a given clinical characteristic differed according to the type of allele carried by the family.

	DN90	rec	O-SD	DN90 vs rec (p value)	DN90 vs O-SD (p value)	rec vs O-SD (p value)
Number of alleles	60 (58%)	43 (42%)	52
Class distribution of families
NA	7 (5%)	5 (8%)	2 (3%)	ns	ns	ns
noFH	22 (14%)	9 (14%)	5 (7%)	ns	ns	ns
FH	20 (13%)	19 (30%)	6 (9%)	0.006	ns	0.002
LFL	44 (29%)	14 (22%)	24 (34%)	ns	ns	ns
LFS	59 (39%)	16 (25%)	33 (47%)	ns	ns	0.012
Total	152 (100%)	63 (100%)	70 (100%)
Families with individuals exhibiting multiple tumours	96 (63%)	28 (44%)	40 (57%)	0.015	ns	ns