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Relationship of clinical variables to functional classification of p53 germline SD alleles based on DN90.
| SD | DN90 | rec | DN90 vs rec (p value) |
|
|---|---|---|---|---|
| Number of alleles Class distribution of families |
69 (100%) | 54 (78%) | 15 (22%) | |
| NA | 7 | 6 (4%) | 1 (4%) | ns |
| noFH | 25 | 21 (14%) | 4 (15% ) | ns |
| FH | 24 | 19 (13%) | 5 (19%) | ns |
| LFL | 45 | 41 (28%) | 4 (15% ) | ns |
| LFS | 70 | 58 (40%) | 12 (46%) | ns |
| Total | 171 | 145 (100%) | 26 (100%) | |
| Families with individuals exhibiting multiple tumours |
107 | 93 (64%) | 14 (54%) | ns |
