Table 2.
ROC curves analysis of SLEDAI-2000 index as a predictor of increase in therapy
| Cut-off score | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | Youden index |
|---|---|---|---|---|---|
| 2 | 87.7 (83.2, 91.1) | 43.0 (38.5, 47.6) | 31.1 (27.9, 34.4) | 92.3 (89.5, 94.3) | 0.30 |
| 3 | 71.9 (65.8, 77.3) | 70.7 (66.1, 75.0) | 41.8 (37.5, 46.3) | 89.6 (87.2, 91.6) | 0.42 |
| 4 | 70.8 (64.6, 76.3) | 72.2 (67.5, 76.4) | 42.7 (38.2, 47.2) | 89.3 (87.0, 91.4) | 0.42 |
| 5 | 44.4 (38.0, 51.1) | 87.5 (84.3, 90.1) | 51.0 (45.0, 57.0) | 84.3 (81.9, 86.5) | 0.32 |
| 6 | 42.1 (35.9, 48.6) | 88.1 (84.9, 90.7) | 50.9 (44.7, 57.0) | 83.9 (81.4, 86.0) | 0.30 |
| 7 | 28.4 (22.4, 35.1) | 93.3 (90.7, 95.2) | 55.4 (48.0, 62.6) | 81.6 (79.0, 84.0) | 0.22 |
| 8 | 26.3 (20.6, 32.9) | 93.8 (91.2, 95.7) | 55.6 (47.6, 63.2) | 81.3 (78.7, 83.6) | 0.22 |
| 9 | 17.3 (13.1, 22.4) | 96.7 (95.1, 97.9) | 60.8 (52.0, 69.0) | 80.0 (77.4, 82.3) | 0.14 |
| 10 | 17.3 (13.1, 22.4) | 97.0 (95.3, 98.1) | 62.8 (53.5, 71.1) | 80.0 (77.5, 82.3) | 0.14 |