Table 4.
ROC curves analysis of SLEDAI-2000 index to determine the most appropriate minimal increase in score associated with increase in therapy
| Increase in SLEDAI-2000 score (magnitude) | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | Youden index, % |
|---|---|---|---|---|---|
| ≥1 | 47.4 (41.6, 53.2) | 82.4 (80.0, 84.6) | 44.2 (39.0, 49.5) | 84.2 (81.6, 86.5) | 0.30 |
| ≥2 | 44.9 (39.3, 50.5) | 84.4 (82.2, 86.3) | 45.7 (40.4, 51.2) | 83.9 (81.4, 86.2) | 0.29 |
| ≥3 | 28.7 (23.7, 34.2) | 95.4 (94.0, 96.5) | 64.8 (56.8, 72.0) | 82.0 (79.5, 84.3) | 0.24 |
| ≥4 | 26.2 (21.4, 31.6) | 95.9 (94.5, 96.9) | 65.1 (56.5, 72.8) | 81.6 (79.1, 83.8) | 0.22 |
| ≥5 | 14.6 (10.6, 19.9) | 98.4 (97.4, 99.1) | 73.4 (60.8, 83.1) | 79.7 (77.1, 82.0) | 0.13 |
| ≥6 | 13.7 (9.7, 19.0) | 98.8 (97.9, 99.3) | 77.2 (64.5, 86.3) | 79.6 (77.0, 81.9) | 0.13 |
| ≥7 | 9.0 (6.0, 13.3) | 99.5 (98.7, 99.8) | 85.3 (67.7, 94.1) | 78.8 (76.3, 81.2) | 0.09 |