Table 3.

Biomarkers characterized by risk quintile for each model

	n	Deaths	Deaths/100 PY		Age ≥65 years (%)	Substance ab/dep (%)	CD4 (cells/μL)	HIV RNA (log copies/mL)	AIDS-defining conditions (%)	HGB (g/dL)	FIB 4> 3.25 (%)	eGFR <30 mL/min (%)	Viral hepatitis (%)
				95% CI
HIV and ‘non-HIV’ combined quintiles
1	4379	513	2.2	2.0, 2.3	7.0	20.1	419	2.9	5.7	14.5	0.0	0.1	29.0
2	2011	513	5.1	4.6, 5.5	2.9	38.2	263	3.7	21.9	13.8	0.7	0.4	58.6
3	1510	513	7.2	6.6, 7.8	6.2	35.2	171	4.2	36.4	12.9	18.4	2.2	60.0
4	1057	513	12.0	11.0, 13.1	8.6	44.2	122	4.7	43.3	12.1	38.4	3.5	67.6
5	827	514	18.7	17.2, 20.4	12.0	49.2	48	5.1	60.7	10.8	59.0	14.0	73.4
HIV quintiles
1	3796	513	2.5	2.3, 2.8	0.0	19.1	466	2.7	3.7	14.5	5.9	1.2	42.5
2	2089	513	4.8	4.4, 5.2	0.0	32.4	262	3.7	11.9	13.9	11.5	1.8	50.9
3	1599	513	6.7	6.2, 7.3	6.6	42.2	163	4.0	25.5	13.4	16.9	2.3	54.7
4	1365	513	8.5	8.0, 9.3	10.8	37.1	111	4.6	52.5	12.6	17.4	2.9	47.9
5	935	514	15.2	14.0, 16.6	12.7	50.5	26	5.3	73.5	11.6	23.1	3.7	50.4
‘Non-HIV’ quintiles
1	4051	513	2.3	2.1, 2.6	0.0	23.3	365	3.2	13.7	14.4	0.0	0.0	29.2
2	2083	513	4.9	4.5, 5.4	2.9	20.1	268	3.7	21.8	14.0	0.0	0.4	43.6
3	1664	513	6.4	5.9, 7.0	7.0	48.3	238	3.9	31.4	12.9	4.0	0.8	65.1
4	1104	513	11.0	10.1, 12.0	4.4	42.4	192	4.1	29.3	12.5	52.3	3.9	78.0
5	882	514	16.4	15.1, 17.9	16.6	47.6	142	4.4	39.3	10.8	61.5	14.6	72.5

ab/dep, abuse/dependence; CI, confidence interval; eGFR, estimated Glomerular Filtration Rate; FIB, Fibrosis Index; HGB, haemoglobin; PY, person-years.

FIB 4: (years of age × AST)/(platelets in 10⁹/L × square root of ALT).

eGFR: 186.3 × (serum creatinine – 1.154) × (age – 0.203) × (0.742 for women) × (1.21 if African American).