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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Hypertension. 2011 Jan 17;57(3):577–585. doi: 10.1161/HYPERTENSIONAHA.110.165274

Figure 6. VSMC-specific AT1A-receptor mice have reduced local oxidative stress in the vascular wall after 4 weeks of angiotensin II-dependent hypertension.

Figure 6

Oxidized amino acids in freshly dissected thoracic aorta were quantified by liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) using multiple reaction monitoring (MRM) mode in SMKO (n=11) and control (n=13) mice after 4-weeks of angiotensin II administration. Increased levels of both 3-nitrotyrosine (A) and dityrosine (B) were detected in aortic segments from control mice after angiotensin II infusion. These increases were significantly attenuated in SMKOs by almost 80% for 3-nitrotyrosine (7819±1676 vs. 1768±450 μmol/mol tyrosine; **P<0.005) and by almost 50% for dityrosine (137±27 vs. 74±10μmol/mol tyrosine; #P<0.05).