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. Author manuscript; available in PMC: 2011 Apr 15.
Published in final edited form as: Eur J Neurosci. 2010 May 24;31(11):1946–1959. doi: 10.1111/j.1460-9568.2010.07231.x

Fig. 2.

Fig. 2

Prolonged depolarization to −70 mV dramatically enhanced small-conductance calcium-dependent potassium channel regulation of firing, with a greater effect in lateral dorsal striatum (latDS) than in nucleus accumbens shell (NAS) neurons. (A–C) Depolarization to −70 mV significantly enhanced interspike intervals (ISIs) in both latDS and NAS neurons relative to holding at −90 mV, with a significantly greater effect in the latDS neurons, and with (D) a larger apamin-sensitive portion of the ISI in latDS neurons at −70 mV. bas, baseline; apa, apamin. (E and F) Prolonged depolarization to −70 mV also dramatically enhanced the time-to-peak of the afterhypolarization (AHP), with a significantly greater effect in latDS than in NAS neurons. After apamin administration, there were no differences in the time-to-peak of the AHP. *P < 0.05, **P < 0.01. Vhold, holding potential.