Fig. 3.

Apamin significantly enhanced the instantaneous firing frequency (IFF) in lateral dorsal striatum (latDS) neurons, but had little effect in nucleus accumbens shell (NAS) neurons. (A and B) Sample traces showing action potential (AP) firing during a 2-s depolarization at the second step above rheobase in (A) latDS neurons and (B) NAS neurons. Current steps for the sample traces are 140 and 100 pA for the latDS and NAS examples, respectively. (C and D) Graphs for the examples in A and B showing the IFF for each AP pair across the AP train in (C) latDS neurons and (D) NAS neurons. IFF values across the AP train were fitted with a line, and the initial and final IFF values from the AP train were derived from this line fit. (E and F) Grouped data for initial IFF values from the AP train before and after apamin administration in (E) latDS neurons and (F) NAS neurons. (G and H) Grouped data showing final IFF values from the AP train and initial IFF values before and after apamin administration in (G) latDS neurons and (H) NAS neurons. Data for the initial IFF values are the same as shown in E and F, and error bars are removed for clarity. *P < 0.05 for initial IFF values for basal latDS vs. latDS with apamin and basal NAS. ^#P < 0.05 for smaller final vs. initial IFF in NAS neurons.