Figure 2.

CRF potentiates AMPAR-mediated synaptic transmission onto the VTA only in cocaine-treated mice. A, B, CRF (1 μm) did not increase AMPAR EPSCs evoked at −70 mV in neurons from naive (A) and saline-treated (B) mice. C, Potentiation of VTA AMPAR EPSCs during CRF application from cocaine-treated mice. Insets show representative traces of AMPAR EPSCs before (baseline) and 7 min after application of CRF. The stimulation artifact was eliminated from all traces. D, Summary of data from A–C, representing the mean ± SEM averaged from 5–10 min after CRF application. ***p < 0.001, one-way ANOVA with Bonferroni's post test across groups during CRF application.