Table 1.
Pro-tumorigenic genes activated in colon tumor cells by S100A8/A9
| Gene | Accession Number | Known Functions |
|---|---|---|
| Cxcl1 | NM_008176.1 | chemokine, promote angiogenesis, mobilization of leukocytes including MDSC |
| C3 | NM_009778.1 | complement component 3, mobilization of HSC into tumor stroma |
| Slc39a10 | NM_172653.2 | zinc transporter, belongs to Zip family (Zip10), upregulated in endometrial carcinoma, promote migration of breast tumor cells |
| Nfkbiz | NM_030612 | IκB family, IL-6 activator, modulates NF-κb transcription |
| Lcn2 | NM_008491.1 | lipocalin 2, upregulated in inflammation, has pro and anti-tumor effects |
| Fas | NM_007987.1 | apoptosis, TNF family member with the death domain |
| Zc3h12a | NM_153159.1 | zinc finger family, RNase, controls stability of inflammatory genes, mediates CCL2 induced angiogenesis, macrophage activation |
| Enpp2 | NM_015744.1 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, autotaxin, promotes tumor cell migration (invadopodia), angiogenesis, and its expression is upregulated in several kinds of carcinomas |
| Ccl5 | NM_013653.1 | chemokine, stimulate angiogenesis |
| Ccl2 | NM_013653.2 | chemokine, potent stimulator of angiogenesis |
| Ccl7 | NM_013653.3 | chemokine, promote macrophage infiltration into tumors |
| Gbp4 | NM_018734.2 | guanylate binding protein 4; gene family induced during macrophage activation, IFN gamma inducible, GTPase |
| Slpi | NM_011414.1 | secretory leucocyte peptidase inhibitor, upregulated in tumors, secreted inhibitor which protects epithelial tissues from serine proteases, implicated in wound healing |
| Plf2 | NM_011118.1 | proliferin-2, HSC growth factor, associated with angiogenesis and wound healing |