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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: FEBS J. 2010 Dec 30;278(4):643–653. doi: 10.1111/j.1742-4658.2010.07985.x

Figure 1. Effects of inactivation of the SH3 and SH2 domains on the Src regulation of NMDAR activity.

Figure 1

A: An example showing NR1-1a/NR2A receptor-mediated whole-cell currents before and during PP2 application recorded from HEK-293 cells co-transfected with cDNAs of n-Src/Y535F; B: An example of the current-voltage relationship recorded before (control) and during PP2 application from a cells co-transfected with n-Src/Y535F; C: Summary data (mean ± SEM) showing NMDAR peak current density recorded in HEK-293 cells transfected without (“−”) or with (“+”) v-Src. D: Summary data showing effects of PP2 application on peak amplitudes of NMDAR currents, which were normalized with those before PP2 application (= 100%, dashed line), recorded from cells co-transfected without (“−“) or with cDNAs of n-Src mutants as indicated; #: p<0.05, ##: p<0.01 (Independent group t-test). Values in brackets indicate the number of cells tested.