Skip to main content
. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: FEBS J. 2010 Dec 30;278(4):643–653. doi: 10.1111/j.1742-4658.2010.07985.x

Table 1.

n-Src constructs

n-Src Constructs Corresponding c-Src Mutation Mutation Location Phenotype
Wild-type None None Native
Y535F Y527F C-tail Constitutively active
K303R/Y535F K297R/Y527F Kinase domain and C-tail Kinase dead
D101N/Y535F D99N/Y527F SH3 domain and C-tail SH3 domain dysfunction
R183K/Y535F R175K/Y527F SH2 domain and C-tail SH2 domain dysfunction
D101N/R183K/Y535F D99N/R175K/Y527F SH3, SH2 domain and C-tail SH3 and SH2 domain dysfunction
Y535FΔ1–258 Y527FΔ1–250 N-terminal, SH3, SH2 domain and C-tail Deletion of N-terminal, SH3 and SH2 domain of active n-Src
K303R/Y535F Δ1–258 K297R/Y527F Δ1–250 N-terminal, SH3, SH2, kinase domain and C-tail Deletion of N-terminal, SH3 and SH2 domain of kinase dead n-Src

The n-Src constructs are listed by the residue(s) mutated, corresponding mutation(s) in chicken c-Src, and respective phenotype based on the mutation(s).