Figure 1. VACV infection in single-cytokine deficient mice did not alter the outcome of infection.

C57BL/6 (n = 6), IL-12/23^−/− (n = 4), TNFR^−/− mice (n = 7), IFNγ^−/− (n = 6) and iNOS^−/− (n = 6) animals were infected with 10⁷ p.f.u. of VACV-WR by tail scarification. (A) Weight curve of C57BL/6, IL-12/23^−/−, TNFR^−/− mice. (B) Weight curve of IFNγ^−/− and iNOS^−/− mice. (C) WT, IFNγ^−/− and iNOS^−/− animals were euthanized at days 3, 5 and 7 post-infection (p.i.) and viral titers in tails were assessed by titration in BSC-40 cells. Bars represent the mean and standard error (SEM). The results shown are representative of two separate experiments.