Figure 5. B-cell deficient mice did not show any signs of disseminated disease, but had delayed viral clearance.

µMT mice (n = 6) were infected with 10⁷ p.f.u. of VACV-WR by tail scarification. (A) Weight curve of µMT mice infected with VACV-WR or mock-infected. (B) The same animals were followed for 60 days to compute mean survival. (C) Viral titers were determined in tails of C57BL/6 and µMT mice at days 10, 15, 28 and 60 p.i. (*p<0.05 and **p<0.01, t test). (D) Viral titers were determined in ovaries of µMT mice at days 10, 15, 28 and 60 p.i. and of Rag1 ^−/− mice at days 10 and 15 p.i.(*p<0.05 and **p<0.01, t test). Bars represent mean and standard error (SEM). Results shown are representative of two experiments.