Figure 1.

(a) Ultrasound imagery of the prostate provides poor soft tissue resolution, while (b) high resolution MRI (ex vivo image shown) shows internal anatomical details of the prostate with greater clarity. Ground truth for CaP extent is obtained only through histopathologic analysis of (c) the corresponding hematoxylin and eosin stained tissue section. The histopathologic CaP extent on (c) can be mapped onto the MRI in (b) by either (d) manually labeling the MRI using histology as a visual reference or (e) automatically mapping CaP extent from (c) via image registration. Note that the morphology of the CaP extent is better preserved in the mapping from (c) onto (e) as compared to (d).