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Establishing disease signatures on in vivo multiprotocol MRI using MACMI for registration of (a) WMH sections to corresponding (d) T2-w and (e) T1-w MRI. Alignment of the T2-w and T1-w MRI allows generation of (c) the multiattribute MRI comprised of coregistered multiprotocol MRI. MACMI is used to align (a) WMH to (c) the multiattribute MRI. CaP extent on the (b) elastically registered WMH is mapped directly onto both MR images in (c).
