Comparison of elastic registration accuracy for MACMI and pairwise MI alignment of n=20 pairs of synthetic PD MRI with coregistered T1-w and T2-w MRI brain images. The measures illustrated below correspond to (i) error of recovered deformation field (in mm) in terms of FMAD and FRMS and (ii) distance (DL2) between the undeformed and recovered PD MRI. MACMI results are significantly more accurate compared to either PW approach (p-values for both tests shown). The best values are indicated in bold.