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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Curr Opin Cell Biol. 2010 Nov 18;23(2):184–189. doi: 10.1016/j.ceb.2010.10.009

Figure 1. Molecular components of chaperone-mediated autophagy.

Figure 1

Scheme of the sequential steps that mediate degradation of cytosolic proteins through chaperone-mediated autophagy (CMA): 1. Recognition of cytosolic proteins by hsc70 and its co-chaperones. 2. Binding of the chaperone/substrate complex to the receptor at the lysosomal membrane. 3. Unfolding of the substrate protein. 4. Translocation across the lysosomal membrane. 5. Degradation in the lysosomal lumen. Insets: A. Regulation of the stability of the CMA translocation complex B. Dynamics of the CMA receptor at the lysosomal membrane. .