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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Curr Opin Cell Biol. 2010 Nov 18;23(2):184–189. doi: 10.1016/j.ceb.2010.10.009

Figure 2. CMA dysfunction in protein conformational disorders.

Figure 2

CMA contributes to protein quality control and maintenance of the stability of the proteome. Consequently, alterations in this autophagic pathway have been linked to different protein conformational disorders. This scheme displays some of these disorders in kidney and in the central nervous system, and illustrates the potential negative effect that changes with age in CMA activity have in the progression of these diseases.