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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Mol Cancer Res. 2011 Mar 7;9(4):418–429. doi: 10.1158/1541-7786.MCR-10-0511

Figure 2.

Figure 2

EZH2 depletion induces a cellular senescence phenotype in melanoma cells. Cell proliferation rate, SA-β-gal expression, and cell cycle distribution were determined following EZH2 depletion with a small-interfering RNA. (A) Growth curves of EZH2 siRNA (siE)- and control siRNA (siN)-treated UCD-Mel-N, SK-Mel-173, and SK-Mel-119 cells. Each data point represents the average of three independent measurements. Error bars indicate the standard deviation. (B) SA-β-gal staining in melanoma cells following EZH2 depletion (siE) or control siRNA transfection (siN). (C) Cell cycle analysis of melanoma cells with EZH2 depletion. Cell phase distribution from 1/3 representative experiments performed for control siRNA (siN) and siEZH2 (siE)-treated cells.