Table 3.
Patient* | IC50 of HA22 (nM) | IC50 of HA22-LR-8M (nM) | Binding† (%) |
1 | 0.021 | 97 | 0.022 |
2 | 0.13 | >400 | <0.033 |
3 | 0.56 | >400 | <0.14 |
4 | 2.8 | 140 | 1.9 |
5 | 9.1 | >400 | <2.3 |
6 | 0.35 | 8.3 | 4.2 |
7 | 0.16 | 0.57 | 28 |
8 | 0.096 | 0.26 | 37 |
9 | 0.08 | 0.19 | 42 |
*Patients were treated with HA22 (three to five cycles) and developed neutralizing antibodies.
†IC50 ratio (HA22/HA22-LR-8M) x 100.