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. 2011 Mar 21;108(14):5753–5758. doi: 10.1073/pnas.1016430108

Fig. 3.

Fig. 3.

PI3Kγ knockout mice showed amelioration of HFD-induced hepatic steatosis. (A) Hematoxylin and eosin-stained sections of liver from Pik3cg+/+ (+/+) and Pik3cg−/− (−/−) mice on a ND or a HFD. (Scale bar, 100 μm.) (B) Triglyceride (TG) content in liver of mice on a HFD (n = 7–8). (C) Expression levels of mRNA related to fatty acid metabolism in liver of fasted mice (n = 7–8). (D–F) Expression levels of genes encoded macrophage-related protein (D), proinflammatory genes (E), and M2 macrophage-specific genes (normalized to Cd68, F) in liver (n = 7–8). #P < 0.05 for a HFD compared with ND. *P < 0.05 and **P < 0.01 for Pik3cg−/− mice compared with Pik3cg+/+ controls.