Table 1.

Physiologic parameters and plasma analyses

Physiological parameters	WT	Liv-DGAT2
Body weight (g)	25.2 ± 0.3	24.8 ± 0.4
Lean mass (% of body weight)	71.2 ± 0.7	72.2 ± 0.7
Fat mass (% of body weight)	10.6 ± 0.8	9.6 ± 0.7
Energy expenditure [kcal/(kg-h)]	18.2 ± 0.4	18.8 ± 0.4
Caloric intake [kcal/(kg-h)]	17.5 ± 1.9	13.9 ± 2.1
Activity (counts/h)	136.9 ± 21.2	130.7 ± 15.3
RQ during light hours	0.89 ± 0.01	0.86 ± 0.01*
RQ during dark hours	0.95 ± 0.01	0.95 ± 0.01
Recovery from presurgery BW (%)	101.8 ± 1.8	102.6 ± 2.4
Plasma analyses
Fasting insulin (μU/mL)	16.3 ± 4.4	14.5 ± 2.5
Clamp insulin (μU/mL)	53.1 ± 8.3	47.6 ± 7.2
Fasting FA (mEq/L)	1.1 ± 0.4	0.5 ± 0.2
Insulin-stimulated FA (mEq/L)	0.5 ± 0.2	0.4 ± 0.2
Insulin suppression of FA (%)	56.5 ± 9.2	32.6 ± 19.6*
Triglycerides (mg/dL)	87.5 ± 10.1	65.7 ± 11.4
Total cholesterol (mg/dL)	141.9 ± 9.9	134.7 ± 13.0
High-density lipoprotein cholesterol (mg/dL)	80.8 ± 4.8	56.4 ± 10.5
Interleukin-1β (pg/mL)	6.2 ± 1.6	12.6 ± 3.7
IFN-γ (pg/mL)	3.4 ± 0.3	3.3 ± 0.4
Interleukin-6 (pg/mL)	18.5 ± 2.2	23.4 ± 8.0
Interleukin-10 (pg/mL)	58.2 ± 6.6	48.7 ± 1.8
Tumor necrosis factor-α (pg/mL)	15.3 ± 6.4	8.1 ± 1.3

BW, body weight; FA, fatty acids; RQ, respiratory quotient. *P < 0.05 vs. WT. Data are represented as mean ± SEM.