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Charge-swap double-mutant rescue of redox modulation. (A) 4-CY effects (ΔIss) measured on double-mutations of Kvβ1. The error bars are SEM from 5 to 15 independent patches. ***P < 0.001 vs. Kvβ1 WT; unpaired Student's t test. (B) K+ current recorded on inside-out patches expressing Kv1.1 with Kvβ1 WT, R48E, E349R, or the double mutant R48E-E349R, before (black) and after (red) perfusion of 4-CY. Scale bars represent 300 pA and 10 ms.
