Table 2.

Co-occurrence of core cardiac TF peaks

Transcription factors	Peaks	Genes	Examples
1 TF	120,278	14,132	Hand1, Irx4, Tnni3k,
≥ 2 TF	18,343	9,824	Tbx20, Mef2c, Hopx, Scn5a, Gja5
≥ 3 TF	6,434	4,782	Srf, Gata4, Gata6, Mef2d, Nppa, Nppb, Mybpc3
≥ 4 TF	1,715	1,623	Nkx2-5 Mef2a, Tbx5, Hand2, Pparg, Myocd
5 TF	287	286	Ankrd1, Atp2a2, Ryr2, Fhl2, Myh7

Co-occurring peaks were defined as peaks separated by 500 bp or less. Peaks were mapped to the nearest gene within 100 kb. Some genes were associated with multiple peaks. Ankrd1, ankyrin repeat domain 1; Atp2a2, ATPase, Ca⁺⁺ transporting, cardiac muscle, slow twitch; Fhl2, four and a half LIM domains 2; Gata6, GATA-binding protein 6; Gja5, gap junction protein, α5; Hand1, heart and neural crest derivatives expressed transcript 1; Hand2, heart and neural crest derivatives expressed transcript 2; Hopx, HOP homeobox; Irx4, Iroquois homeobox 4; Mef2c, myocyte enhancer factor 2C; Mef2d, myocyte enhancer factor 2D; Myh7, myosin, heavy chain 7, cardiac muscle, β; Myocd, myocardin; Pparg, peroxisome proliferator-activated receptor γ; Ryr2, cardiac muscle ryanodine receptor-calcium release; Scn5a, sodium channel voltage-gated, type V α subunit; Tbx20, T-box 20; Tnni3k, TNNI3 interacting kinase.