. 2011 Apr;178(4):1416–1428. doi: 10.1016/j.ajpath.2010.12.051

Table 1.

Expression of Potential Phagocytic Receptors in Central Nervous System Cells

Receptor	Ligand	Relevance	Expression detected			References
Receptor	Ligand	Relevance	Microglia	Astrocytes	Neurons	References
Phosphatidylserine receptors
BAI1	PS	Uptake of apoptotic cells	×	×	×	1
TIM4	PS	Uptake of apoptotic cells				1
Scavenger family receptors	PS	Uptake of apoptotic cells				1, 89
Opsonin receptors
MerTK	Gas6 (binds PS)	Uptake of POS, apoptotic cells		×	×	3, 26
MerTK	Gas6 (binds PS)	Gas 6 production^⁎		×	×	3, 26
αvβ_3/5 integrin	Mfge8 (binds PS)	Uptake of apoptotic cells, uptake of Aβ	×	×	×	3, 79
αvβ_3/5 integrin	Mfge8 (binds PS)	MFGE8 production^⁎		×		3, 79
Complement receptor	Complement	Uptake of apoptotic cells, uptake of Aβ	×	×	×	22, 55
Complement receptor	Complement	Complement production^⁎	×	×	×	22, 55
FcR	Immunoglobulins	Uptake of apoptotic cells, uptake of Aβ	×	×	×	64, 90
FcR	Immunoglobulins	Immunoglobulin production^⁎				64, 90
Pattern recognition receptors
TLRs/CD14	Aβ	Uptake of apoptotic cells, uptake of Aβ	×	×	×	3, 91, 92, 93
FPRL1	Aβ	Uptake of Aβ	×	×	×	94, 95
RAGE	Aβ	Uptake of Aβ, BBB-associated Aβ receptor	×	×	×	5, 95, 96, 97
CD36 scavenger receptor	Aβ, α-synuclein	Uptake of Aβ	×	×		42, 95, 98, 99
Lipoprotein receptors
LDLR	ApoE	Uptake of Aβ-ApoE complexes, mediate Aβ-induced changes in ApoE production		×	×	3, 95
LDLR	ApoE	ApoE production^⁎		×		3, 95
LRP1	ApoE	Uptake of Aβ-ApoE complexes, BBB-associated Aβ receptor		×	×	3, 95
LRP1	ApoE	Uptake of Aβ-ApoJ complexes		×		3, 95
LRP2/megalin	Clusterin (ApoJ)	Clusterin production^⁎	×	×	×	55, 75, 95

Aβ, amyloid-β; Apo, apolipoprotein; BAI1, brain-specific angiogenesis inhibitor-1; BBB, blood-brain barrier; FcR, Fc receptor; FPRL1, formyl peptide receptor-like 1; Gas6, growth-arrest specific 6; LDLR, low density lipoprotein receptor; LRP, low density lipoprotein receptor-related; MerTK, Mer receptor tyrosine kinase; Mfge8, milk fat globule-EGF factor 8 (also known as lactadherin); POS, photoreceptor outer segments; PS, phosphatidylserine; RAGE, receptor for advanced glycation endproducts; TIM4, T-cell immunoglobulin and mucin-domain-containing molecule 4; TLR, Toll-like receptor.

^⁎

Asterisk indicates that the ligand is an opsonin (bridging molecule), rather than the direct target of the phagocytic receptor.