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. 2011 Apr;178(4):1870–1880. doi: 10.1016/j.ajpath.2010.12.044

Figure 1.

Figure 1

Pregnancy enhances B16 tumor growth, metastasis, and mortality. A: The B16 melanoma cell line was injected in nonpregnant and pregnant mice on day 5 of gestation. B: Tumor volume measured at different points. D indicates day. Volume was also measured using FDG PET on D16. Data are expressed as mean ± SE. *P < 0.05; **P < 0.01 (Student's t-test). C: FDG PET imaging showing necrotic areas in the tumor. D: The percentage of necrotic volume within the tumor on D16 after injection was calculated based on FDG PET imaging in 17 pregnant and 20 nonpregnant mice. Data are expressed as mean ± SE. P = 0.065, Student's t-test. E: Frequency of metastasis of B16-BL6 melanoma on D16. Data are given as mean ± SE, *P < 0.05, Fischer's exact test. F: Survival was better in nonpregnant (n = 16) compared with pregnant (n = 22) mice by Kaplan-Meier analysis (P = 0.0158).