Table 1.
Expression of mOGG1 and hOGG1 in TG and Control Mice
| Organ or tissue | TG mice |
Wild-type mice |
||
|---|---|---|---|---|
| mOGG1 | hOGG1 | mOGG1 | hOGG1 | |
| Liver | 0.41 | 227 | 0.7 | ND |
| Kidney | 0.7 | 42 | 1.1 | ND |
| Heart | 1.69 | 136 | 1.55 | ND |
| Spleen | 0.24 | 1.4 | 0.11 | ND |
| Lung | 0.36 | 12 | 0.38 | ND |
| Brain | 1.82 | 22 | 1.0 | ND |
| Bone marrow | 0.2 | 31 | 0.22 | ND |
| Brown fat | 2.6 | 110 | 3.6 | ND |
| White fat | 0.53 | 4 | 0.9 | ND |
| Skeletal muscle | 2.65 | 347 | 1.82 | ND |
| Stomach | 0.21 | 21 | 0.13 | ND |
| Small intestine | 0.07 | 10 | 0.07 | ND |
| Colon | 0.3 | 7 | 0.13 | ND |
| Testis | 1.22 | 2.8 | 1.53 | ND |
The mRNA levels were normalized against endogenous mouse β-actin and expressed as the mean value from two mMT-hOGG1 TG mice and two wild-type control mice; all mice were male, aged 11 months, and derived from the same TG founder.
ND, not detectable.