Table 2.
Correlation of Expression of ADAM17 and FZD7 With Various Clinicopathologic Patient Characteristics
| ADAM17 |
FZD7 |
|||||
|---|---|---|---|---|---|---|
| Variable | Negative | Positive | P value⁎ | Negative | Positive | P value⁎ |
| Sex | 0.668 | 0.161 | ||||
| Male | 214 (73) | 81 (27) | 182 (62) | 111 (38) | ||
| Female | 133 (75) | 45 (25) | 120 (69) | 54 (31) | ||
| Age, years | 0.723 | 0.125 | ||||
| <68 | 128 (74) | 44 (26) | 117 (68) | 55 (32) | ||
| ≥68 | 140 (72) | 53 (28) | 113 (60) | 76 (40) | ||
| Pathologic tumor stage | 0.563 | 0.560 | ||||
| pT1 | 44 (76) | 14 (24) | 33 (75) | 13 (25) | ||
| pT2 | 43 (80) | 11 (20) | 33 (60) | 22 (40) | ||
| pT3 | 132 (71) | 55 (29) | 119 (63) | 71 (37) | ||
| pT4 | 127 (74) | 45 (26) | 111 (50) | 58 (34) | ||
| Nodal status | 0.525 | 0.627 | ||||
| pN0 | 103 (77) | 31 (23) | 86 (66) | 45 (34) | ||
| pN1 | 50 (70) | 21 (30) | 39 (56) | 31 (44) | ||
| pN2 | 54 (69) | 24 (31) | 51 (67) | 25 (33) | ||
| pN3 | 135 (73) | 49 (27) | 122 (66) | 63 (34) | ||
| Tumor stage | 0.309 | 0.412 | ||||
| IA | 10 (71) | 4 (29) | 9 (69) | 4 (31) | ||
| IB | 8 (73) | 3 (27) | 10 (91) | 1 (9) | ||
| IIA | 22 (79) | 6 (21) | 13 (48) | 14 (52) | ||
| IIB | 20 (74) | 7 (26) | 15 (56) | 12 (44) | ||
| IIIA | 29 (78) | 8 (22) | 25 (68) | 12 (32) | ||
| IIIB | 46 (70) | 20 (30) | 45 (69) | 20 (31) | ||
| IIIC | 45 (85) | 8 (15) | 37 (69) | 17 (31) | ||
| IV | 42 (63) | 25 (37) | 36 (55) | 30 (45) | ||
| Tumor grade | 0.467 | 0.308 | ||||
| G1/G2 | 81 (70) | 34 (30) | 96 (61) | 45 (39) | ||
| G3/G4 | 254 (74) | 89 (26) | 223 (66) | 114 (34) | ||
| Laurén classification | 0.277 | 0.005 | ||||
| Intestinal | 128 (71) | 52 (29) | 103 (57) | 78 (43) | ||
| Diffuse | 151 (71) | 61 (29) | 150 (73) | 57 (27) | ||
| Mixed | 35 (83) | 7 (17) | 25 (61) | 16 (39) | ||
| FZD7 | <0.001 | |||||
| Negative (0) | 232 (80) | 60 (20) | ||||
| Positive (>0) | 99 (61) | 63 (39) | ||||
Values are given as No. (%).
⁎
Determined using the Mann-Whitney test or the Fisher exact test.