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. 2011 Apr;178(4):1591–1604. doi: 10.1016/j.ajpath.2010.12.020

Figure 2.

Figure 2

Effect of PTP1B deficiency on the TNF-α– and IL-6–mediated early responses after PH. The PH was performed in PTP1B+/+ and PTP1B−/− mice, and liver and serum samples were collected at the indicated periods. A: Serum levels of TNF-α (left) and IL-6 (right) after PH. Results are given as the mean ± SEM (n = 4–6). *P < 0.05 for PTP1B−/− versus PTP1B+/+ mice. B: Western blot analysis of regenerating livers was performed in PTP1B+/+ and PTP1B−/− mice at the indicated periods. Total protein (50 μg) was analyzed by Western blot with the antibodies against phospho-JNK (Thr183/Tyr185), JNK, phospho-c-Jun (Ser73), phospho-STAT3 (Tyr705), and STAT3. Representative autoradiograms of three independent series of PH in each genotype are shown.