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. 2011 Apr;178(4):1689–1700. doi: 10.1016/j.ajpath.2010.12.028

Figure 1.

Figure 1

Pneumonic plague in NHPs caused by wild-type and caf1 variant Y. pestis. The lungs of cynomolgus macaques that died of aerosol infection with 400 CFU of either Y. pestis CO92 (A–C) or Y. pestis CAC1 (caf1A::IS1541) (D–F) were removed during necropsy. Lung lobes were perfused via bronchi with 10% formalin, embedded in paraffin, thin sectioned, and stained with H&E. Arrows indicate bacterial colonies. The boxes in panels A and D identify the areas of enlargement in panels B and E. The boxes in panels B and E identify the areas of enlargement in panels C and F. Original magnification: ×100 (A and D); ×200 (B and E); ×400 (C and F).