Figure 8.

Restored type 1 immune activation of granuloma CD4 T cells by removal of IL-10. Total cells isolated from the airway lumen and granuloma of mycobacterium-infected wild-type (wt) and IL-10 knock-out (KO) mice were cultured with or without stimulation by mycobacterial antigens and subject to cell surface and intracellular cytokine staining and flow cytometry. Dot plots are representative of three sets of cell preparations (each set of cell preparation was pooled from three mice). IFN-γ, interferon-γ.