FIG. 6.
Antitumor effect of siRNAs in CT-26 tumor-bearing mice. PEI-g-PEG-RGD/siVEGFR, PEI-g-PEG/siVEGFR, PEI-g-PEG-RGD/siLuc, and PEI-g-PEG/siLuc complexes were injected into mice intravenously twice a week. Day 1 corresponds to 2 weeks after inoculation of CT-26 cells when the tumor volume was ∼65–70 mm3. Tumor diameters were measured at a regular interval for up to 11 days with calipers. Results represent the means standard deviation (n = 5). *P < 0.05 compared to PEI-g-PEG-RGD/siVEGFR group.