Table 1.
Molecules Regulating SVZ Neuroblast Migration
| Families of molecules | Constitutive SVZ-RMS-OB migration | Emigration to Model of Stroke |
|---|---|---|
| Chemoattractant (ligand/receptor) | BDNF/TrkB | ? |
| GDNF/GFRα1 | ? | |
| VEGF/VEGFR-1,2 | VEGF/VEGFR-2 | |
| ProK2/ProKR2 | ? | |
| Netrin-1 | ? | |
| Anosmin-1 | ? | |
| HGF/Met | ? | |
| SHH/Patched | ? | |
| ? | SDF-1 CXCR4 |
|
| ? | MCP-1/CCR2 | |
| ? | Osteopontin | |
| ? | Ang-1/Tie-2 | |
| Chemorepellant (ligand/receptor) | Slit1,2/Robo2,3 | ? |
| Signaling (ligand/receptor) | Ephrin-B2/EphB2 | ? |
| Reelin/disabled | ? | |
| Neuregulin/ErbB4 | ? | |
| EGF/ErbB1 | ? | |
| FGF2/FGFR1 | ? | |
| NPY/Y1 | ? | |
| Adhesion (ECM or homotypic) | NCAM/NCAM | ? |
| PSA-NCAM | ? | |
| α6β1 Integrin/Laminin | ? | |
| Tenascin | ? | |
| Connexins 43 & 45 | ? | |
| Matrix metaloproteinases | ? | MMP(s) |
| Neurotransmitters | GABA | ? |
| Glutamate | ? | |
| Cytoskeletal Proteins | Dcx | ? |
?, unknown.