Table 3.

Evolution in specific cognitive functions over 1 year in subjects exposed to general anesthesia (GA, n=184) and regional anesthesia (RA, n=86).

Cognitive function	GA effect		GA*Timea effect
Linear Mixed Model	beta (SE)	p	beta (SE)	p
Reaction timeb	−0.014(0.019)	0.46	0.0006 (0.002)	0.80
Geometric form association	−0.18 (1.55)	0.91	−0.17(0.16)	0.28
Verbal fluency	−0.92 (1.21)	0.45	0.040 (0.069)	0.56
Implicit memory	−0.56 (0.27)	0.04	0.008(0.038)	0.83
Narrative recall	−1.15 (0.96)	0.23	0.014(0.058)	0.80
Logistic Mixed Model	OR [95%CI]	p	OR [95%CI]	p
Attention dual task	0.97 [0.57–1.65]	0.90	0.99 [0.92–1.06]	0.74
Constructional praxis	2.06 [1.03–4.12]	0.04	0.88 [0.80–0.97]	0.01
Logical visual series	0.79 [0.42–1.51]	0.48	0.96 [0.89–1.05]	0.39
Object naming	0.78 [0.41–1.49]	0.45	1.01 [0.93–1.10]	0.75
Immediate verbal recall	1.58 [0.85–2.94]	0.15	0.92 [0.84–1.00]	0.06
Visuospatial span	1.10 [0.66–1.82]	0.72	1.04 [0.98–1.11]	0.20
Delayed verbal recall	1.52 [0.67–3.46]	0.32	1.00 [0.90–1.11]	0.99
Delayed visual recall	1.04 [0.60–1.82]	0.88	0.99 [0.92–1.06]	0.67
Name-face pair recall	0.87 [0.45–1.70]	0.69	0.97 [0.90–1.05]	0.50

Each (linear or logistic) model included age, gender, education level, time, ASA score, ApoE4, anesthesia type, and, the interaction between time and anesthesia.

^atime = number of months between inclusion and follow-up.

^blog-transformed values.