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. 2011 Jan 5;31(1):15–25. doi: 10.1523/JNEUROSCI.2538-10.2011

Figure 5.

Figure 5.

Both amplitude and frequency of mEPSCs are enhanced in GABAergic interneurons, but not pyramidal neurons. E18 mice cortical neurons were treated at DIV6 with 1 nm NRG1 for 2 d and were recorded at DIV12. A, Representative traces of mEPSCs from one control and one NRG1-treated GABAergic interneuron in whole-cell configuration. Calibration: 40 pA, 50 ms. B, Cumulative distribution for mEPSC interevent intervals and amplitude in control and NRG1-treated GABAergic interneurons in A (Kolmogorov–Smirnov test; p < 0.01). C, Histogram summary of data (mean ± SEM; control, 2.10 ± 0.17 Hz, 26.9 ± 0.65 pA, n = 14 cells; NRG1, 3.00 ± 0.29 Hz, 33.4 ± 1.18 pA, n = 15 cells; *p < 0.05; **p < 0.01). D, Representative traces of mEPSCs from one control and one NRG1-treated pyramidal neuron in whole-cell configuration. Calibration: 40 pA, 200 ms. E, Cumulative distribution for mEPSC interevent intervals and amplitude in control and NRG1-treated pyramidal neurons in D (Kolmogorov–Smirnov test; p > 0.05). F, Histogram summary of data (mean ± SEM; control 1.09 ± 0.10 Hz, 23.9 ± 0.83 pA, n = 15 cells; NRG1, 1.16 ± 0.11 Hz, 25.3 ± 1.18 pA, n = 14 cells; p > 0.05).