Table 3. HR-HPV infection and diffuse p16INK4a expression pattern in non-melanoma skin lesions from renal transplant recipients and immunocompetent controls.
Renal transplant recipients NMSC lesions (N=78)
|
Immunocompetent controls NMSC lesions (N=62)
|
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
HR-HPV+
|
HR-HPV−
|
HR-HPV+
|
HR-HPV−
|
|||||||
p16INK4a+ | p16INK4a− | p16INK4a + | p16INK4a− | P | p16INK4a+ | p16INK4a− | p16INK4a+ | p16INK4a− | P | |
SCC | 5 | 1 | 1 | 6 | <0.05 | 4 | 0 | 1 | 12 | <0.001 |
BCC | 4 | 3 | 6 | 22 | 0.06 | 2 | 0 | 4 | 12 | <0.05 |
SCC in situ | 9 | 0 | 14 | 1 | NS | 6 | 1 | 9 | 1 | NS |
KA | 1 | 0 | 0 | 5 | <0.05 | 0 | 0 | 0 | 10 | — |
All lesions | 19 | 4 | 21 | 34 | <0.001 | 12 | 1 | 14 | 35 | <0.001 |
Abbreviations: SCC=squamous cell cancer; BCC=basal cell cancer; KA=keratoacanthoma; HR-HPV=high-risk human papillomavirus; NMSC=non-melanoma skin cancer.