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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Nature. 2011 Mar 13;472(7342):230–233. doi: 10.1038/nature09932

Figure 1. Role of ADP in regulation of AMPK activity.

Figure 1

Figure 1

(a) AMP, but not ADP, allosterically activates AMPK. (b) AMP and ADP protection of AMPK from dephosphorylation. (c) ATP does not protect against dephosphorylation. (d) Mg.ATP competes with the protective effect of ADP on dephosphorylation. Results are displayed as the mean ± S.E.M determined from at least 3 independent experiments. Where appropriate a representative blot (n=3) showing Thr-172 phosphorylation and total α subunit levels is shown.