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. Author manuscript; available in PMC: 2012 Mar 15.
Published in final edited form as: Acc Chem Res. 2010 Dec 22;44(3):180–193. doi: 10.1021/ar1001186

Table 1.

Biological Activity of Bispyrrolinone HIV-1 Protease Inhibitors. 50% Inhibitory Concentration (IC50); Cellular 95% Inhibitory Concentration (CIC95)

Inhibitor N-Terminus C-Terminus IC50 (nM) CIC95 (nM) C/I
L-682,679 Boc NH2 0.6 6,000 10,000
(−)-38 Boc NH2 10 1,500 150
(−)-39 Furanyl Carbamate NH2 1.3 800 615
(−)-40 Furanyl Carbamate NH-t-Bu 3.3 800 242