. Author manuscript; available in PMC: 2012 Mar 15.

Published in final edited form as: Acc Chem Res. 2010 Dec 22;44(3):180–193. doi: 10.1021/ar1001186

Table 2.

HIV-1 Protease Bioassay Data for Monopyrrolinone and Related Amide-based Inhibitors. 50% Inhibitory Concentration (IC₅₀); Cellular 95% Inhibitory Concentration (CIC₉₅)

Inhibitor	IC₅₀ (nM)	CIC₉₅ (nM)	C/I
Indinavir	0.36	25-100	69-277
L-682,679	0.6	6 000	10 000
(−)-39	1.3	800	615
L-697,807	0.03	3	100
(−)-43	2.0	100-250	50-125