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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Ann N Y Acad Sci. 2011 Mar;1220(1):49–59. doi: 10.1111/j.1749-6632.2011.05904.x

Figure 5. Induction of immediate early genes in adrenal gland, CRH mRNA in hypothalamus, and corticosterone in blood after restraint stress is PACAP-dependent.

Figure 5

A. PACAP-dependent regulation of immediate early genes in hypothalamus following restraint stress.

B. Regulation of CRH mRNA in hypothalamus during restraint is abolished in PACAP-deficient mice.

C. Sustained corticosterone secretion induced by restraint stress requires PACAP.

Adapted from Stroth and Eiden, Neuroscience 165: 1025-1030, 2010.