Table 1.

NFAT5 Target Genes not Directly Involved in Osmoadaptation

Target gene	Cell type	Function	Refs.
B cell activating factor (BAFF)	B lymphocytes	B lymphocyte proliferation, differentiation, and IgG production	[14]
beta1,3-Glucuronosyltransferase-I (GlcAT-I)	Nucleus pulposus cells (intervetebral disk)	Glycosaminoglycan synthesis	[15]
Cyclooxygenase-2 (COX-2)	Renal medullary cells	Prostaglandin synthesis	[16]
Cytochrome p450 2E1, 3A	Hepatocytes	Drug metabolism	[17,18]
HIV replication	Macrophages	Binding of NFAT5 to LTR required	[19]
S100A4/metastasin	Cancer cells	Tumor metastasis	[20,21]
Myocyte differentiation	Myoblasts	Cyr61	[22]
TNF-α, lymphotoxin-β	T lymphocytes	Immune responses	[23]
VEGF-C	Macrophages	Lymphangiogenesis	[24]