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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: J Acquir Immune Defic Syndr. 2011 Feb 1;56(2):10.1097/QAI.0b013e3181fe9450. doi: 10.1097/QAI.0b013e3181fe9450

Figure 2. Replication Capacities of bulk RT-Integrase recombinant viruses derived from elite controller and chronic progressor sequences.

Figure 2

Panel A: RC of bulk RT-Integrase recombinant viruses from controllers (EC) and Progressors (Prog) are shown. RC values are normalized to the mean RC of NL4-3, such that an RC of 1.0 indicates equivalent growth to NL4-3, while RC >1 and RC <1 indicate faster or slower growth compared to NL4-3, respectively. Results represent the average of three independent experiments. Horizontal bars indicate median values for each group. Panel B: The rate of viral spread in culture (expressed as fold-increase in % GFP+ cells over the assay period) is shown for controller-derived (red lines) vs. progressor-derived (black lines) viruses. Panel C: RC results of bulk RT-Integrase recombinant viruses are stratified by the absence or presence of amino acid mixtures in the chimeric viral stocks. No significant difference in RC was observed between non-mixture-containng vs. mixture containing recombinant viruses derived from controllers or progressors.