Figure 3.

Attenuated neurodegeneration in the hippocampal CA1 area in Zip-1,3 −/− mutants after KA-induced seizures. A, Representative Fluoro-Jade-stained sections taken from transverse mid-hippocampal sections from +/+ and −/− mutant mice show less CA1 injury in Zip1,3-null mutants following KA seizure activity. B, Fluoro-Jade staining patterns in +/+ and −/− mutant mice reveal region-specific patterns of cell injury. For each mouse, the CA1 FJI was plotted against its CA3 FJI. In wild-type mice (left), the upper left quadrant represents mice with selective and extensive CA1 cell injury but little CA3. This pattern is strikingly reduced in Zip-1,3 −/− mutant mice (right). C, Summary data for the extent of CA1 and CA3 neurodegeneration 24 h after administration of KA (15 mg/kg).