TABLE 1.

Pharmacokinetic Parameters

Subject	Age (days)	Serum Creatinine	Clearance (mL/kg/h)	Vd (mL/kg)	Half life (h)	Kel (h−1)	AUC0–24 (mg*hr/L)
1	6	1.0	27	785	19.9	0.050	493
2	13	1.3	14	1441	73.4	0.013	350
3	14	0.8	12	1522	91.4	0.010	338*
4	14	0.5	18	1021	39.1	0.025	466
5	19	1.2	9	1081	79.4	0.012	493
6	36	0.5	21	711	23.8	0.042	598
7	55	0.3	23	882	27.2	0.036	506
8	59	0.2	14	1635	81.2	0.012	271
Median	17	0.7	16	1051	56	0.02	479
(IQR)	(14–41)	(0.4–1.1)	(13–21)	(858–1461)	(26–80)	(0.01–0.03)	(347–496)

^*Infant 3 was supported by extracorporeal membrane oxygenation.