Table 2.
Individual estimates and standard-two-stage population values for the pharmacokinetic parameters of R (+) and S (−) Ketorolac in 8 infants aged 2.5–6 months.
| R (+) | Ketorolac | S (−) | Ketorolac | ||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | Dose mg/kg |
CL (ml/min) |
CL (ml/min/kg) |
V1 (ml) |
V2 (ml) |
CL (ml/min) |
CL (ml/min/kg) |
V1 (ml) |
V2 (ml) |
| 1 | 1.0 | 10.5 | 1.73 | 1809 | 809 | 82.8 | 13.6 | 3481 | 182 |
| 2 | 1.0 | 3.9 | 0.73 | 738 | 544 | 18.0 | 3.4 | 867 | 609 |
| 3 | 1.0 | 6.7 | 1.05 | 1157 | 708 | 32.7 | 5.1 | 1639 | 201 |
| 4 | 0.5 | 3.7 | 0.63 | 361 | 219 | 5.4 | 0.9 | 348 | 139 |
| 5 | 1.0 | 5.4 | 0.98 | 694 | 803 | 23.7 | 4.3 | 1145 | 171 |
| 6 | 0.5 | 7.1 | 1.27 | 867 | 612 | 30.7 | 5.5 | 1214 | 118 |
| 7 | 1.0 | 8.1 | 1.07 | 1303 | 701 | 29.8 | 3.9 | 1429 | 1093 |
| 8 | 1.0 | 6.6 | 0.88 | 1003 | 869 | 22.3 | 3.0 | 1714 | 214 |
| Mean | 6.5 | 1.04 | 992 | 658 | 30.7 | 5.0 | 1480 | 341 | |
| SDb | 2.2 | 0.34 | 440 | 207 | 22.8 | 3.8 | 920 | 342 | |
| %BSV | 34 | 33 | 44 | 31 | 74 | 76 | 62 | 100 | |
a
Fixed-effect parameters: clearance (CL), central volume of distribution (V1) and peripheral volume of distribution (V2).
b
Standard deviation
c
BSV, between-subject variability